Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 8/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994931 | 0.86 | HTR7 (0.34) | HTR7USP2LMNAMAPK1ALDH1A1 | |
| SCHEMBL7994293 | 0.85 | NPC1 (0.42) | HSP90AA1HSP90B1KCNH2ADRA2CLMNA | |
| SCHEMBL7994719 | 0.85 | HTR7 (0.34) | HTR7KCNH2ADRA2CUSP2LMNA | |
| SCHEMBL7995706 | 0.83 | HSP90AA1 (0.41) | HSP90AA1HSP90B1KCNH2ADRA2CLMNA | |
| SCHEMBL7996749 | 0.83 | HTR7 (0.33) | HSP90AA1HSP90B1HTR7USP2LMNA | |
| SCHEMBL7994851 | 0.83 | EGFR (0.33) | HTR7LMNAMAPK1 | |
| SCHEMBL7997836 | 0.80 | TP53 (0.41) | HSP90AA1HSP90B1KCNH2LMNAALDH1A1 | |
| SCHEMBL8001816 | 0.79 | SMN1; SMN2 (0.46) | LMNAMAPK1ALDH1A1 | |
| SCHEMBL7994645 | 0.73 | HSP90AA1 (0.34) | HSP90AA1HSP90B1 | |
| SCHEMBL7998204 | 0.70 | GRM2 (0.41) | HSP90AA1HSP90B1LMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034578-A1 | COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034578-A1 | COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |