Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231627 | 0.97 | MAPT (0.59) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL2710180 | 0.97 | MAPT (0.59) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL7564083 | 0.85 | POLB (0.52) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL2434953 | 0.83 | GAA (0.59) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL6379699 | 0.83 | GAA (0.59) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL1865824 | 0.83 | CASP6 (0.55) | MAPTTSHRGAAKDM4EPOLB | |
| SCHEMBL2742575 | 0.82 | MAPT (0.58) | MAPTTSHRKDM4EPOLBHPGD | |
| SCHEMBL13520189 | 0.82 | POLB (0.52) | MAPTTSHRKDM4EPOLBHPGD | |
| SCHEMBL7126615 | 0.82 | POLB (0.52) | MAPTTSHRKDM4EPOLBHPGD | |
| SCHEMBL3533309 | 0.81 | POLB (0.51) | MAPTTSHRKDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001055139-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |