Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15887322 | 0.87 | GPR35 (0.51) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL231627 | 0.85 | MAPT (0.59) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL2710180 | 0.85 | MAPT (0.59) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL9375548 | 0.84 | POLB (0.50) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL13519622 | 0.84 | POLB (0.50) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL2742575 | 0.83 | MAPT (0.58) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL7126615 | 0.83 | POLB (0.52) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL18354223 | 0.83 | TSHR (0.54) | MAPK1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL7564083 | 0.83 | POLB (0.52) | POLBMAPK1ALDH1A1TP53HPGD | |
| SCHEMBL8729537 | 0.83 | POLB (0.49) | POLBMAPK1ALDH1A1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926332-B2 | Dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | EGIS GYOGYSZERGYAR ZRT. (HU) | 2018-03-27 | — | — | US | disclosed |
| US-9926332-B2 | Dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | EGIS GYOGYSZERGYAR ZRT. (HU) | 2018-03-27 | — | — | US | disclosed |
| US-20170002020-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | EGIS GYOGYSZERGYAR ZRT. (HU) | 2017-01-05 | — | — | US | disclosed |
| US-20170002020-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | EGIS GYOGYSZERGYAR ZRT. (HU) | 2017-01-05 | — | — | US | disclosed |
| US-20170002020-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | EGIS GYOGYSZERGYAR ZRT. (HU) | 2017-01-05 | — | — | US | disclosed |
| EP-3097110-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Egis Gyógyszergyár Zrt. (HU) | 2016-11-30 | — | — | EP | disclosed |
| WO-2015110848-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EGIS GYÓGYSZERGYÁR ZRT. (HU) | 2015-07-30 | — | — | WO | disclosed |
| WO-2015110848-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EGIS GYÓGYSZERGYÁR ZRT. (HU) | 2015-07-30 | — | — | WO | disclosed |
| US-8362243-B2 | Method for selective localization of active agents at and in mitochondria and corresponding active agents | UGICHEM GESELLSCHAFT FUER ORGANISCHE CHEMIE MBH (AT) | 2013-01-29 | — | — | US | disclosed |
| US-20100009895-A1 | METHOD FOR SELECTIVE LOCALIZATION OF ACTIVE AGENTS AT AND IN MITOCHONDRIA AND CORRESPONDING ACTIVE AGENTS | UGICHEM GESELLSCHAFT FUER ORGANISCHE CHEMIE MBH (AT) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170002020-A1 | NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | GABRB2, GABRB3, GABRA5 | POLB 3066/4885MAPK1 4337/4885ALDH1A1 603/4885 |
| US-20100009895-A1 | METHOD FOR SELECTIVE LOCALIZATION OF ACTIVE AGENTS AT AND IN MITOCHONDRIA AND CORRESPONDING ACTIVE AGENTS | TFB2M, TFAM, SHMT2 | POLB 495/4885MAPK1 3837/4885ALDH1A1 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.