Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985670 | 0.92 | CDK9 (0.42) | ALDH1A1KDM4ECDK9FSCN1NR3C2 | |
| SCHEMBL7988379 | 0.88 | KDM4E (0.50) | KDM4EFLT3HDAC1TP53SMN1; SMN2 | |
| SCHEMBL7987680 | 0.87 | HPGD (0.42) | ALDH1A1KDM4EFLT3HDAC1TP53 | |
| SCHEMBL7987555 | 0.87 | GAA (0.47) | ALDH1A1KDM4EHDAC1CDK9PKM | |
| SCHEMBL7988471 | 0.82 | KDM4E (0.43) | KDM4ESMN1; SMN2GSK3AGSK3BLMNA | |
| SCHEMBL7988506 | 0.82 | NTRK1 (0.48) | NPC1ALDH1A1KDM4ECDK9RAB9A | |
| SCHEMBL8061779 | 0.81 | GSK3B (0.40) | GSK3AGSK3B | |
| SCHEMBL7991550 | 0.81 | GAA (0.45) | ALDH1A1HDAC1PKMGSK3A | |
| SCHEMBL7987961 | 0.80 | MAPT (0.47) | ALDH1A1TP53PKMAURKARPS6KB1 | |
| SCHEMBL7987935 | 0.80 | XDH (0.47) | NPC1ALDH1A1HDAC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |