Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991556 | 0.91 | HPGD (0.43) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL7984655 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL7991594 | 0.90 | HPGD (0.44) | SMN1; SMN2ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL7974420 | 0.90 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7987658 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL7991397 | 0.89 | ABCC8 (0.43) | SMN1; SMN2ALDH1A1HPGDKMT2AIKBKE | |
| SCHEMBL7974466 | 0.89 | HPGD (0.43) | SMN1; SMN2ALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL7985561 | 0.89 | HPGD (0.46) | SMN1; SMN2ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL7984716 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL7985058 | 0.87 | HPGD (0.44) | SMN1; SMN2ALDH1A1HPGDRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |