Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987693 | 0.92 | TDP1 (0.34) | KMT2ACACNA1HLMNAMAPTKDM4E | |
| SCHEMBL7988995 | 0.91 | NR1H4 (0.38) | CACNA1HAAK1BUB1 | |
| SCHEMBL7992102 | 0.91 | HTR2C (0.41) | KMT2AMEN1KDM4EALDH1A1BUB1 | |
| SCHEMBL7989013 | 0.86 | TP53 (0.38) | KMT2ALMNAMAPTMEN1KDM4E | |
| SCHEMBL7974052 | 0.86 | KDM4E (0.42) | CDK9MAPTKDM4ECNR2 | |
| SCHEMBL7974433 | 0.83 | TP53 (0.40) | KMT2AMAPTMEN1 | |
| SCHEMBL7991771 | 0.82 | KMT2A (0.39) | KMT2ALMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL7974264 | 0.81 | HTR2C (0.40) | CYP11B1CYP11B2AAK1BUB1 | |
| SCHEMBL7987776 | 0.80 | KDM4E (0.41) | KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL7991770 | 0.80 | HTR2C (0.39) | AAK1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |