Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 3/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992102 | 0.88 | HTR2C (0.41) | AURKARPS6KB1KDM4EMEN1ALDH1A1 | |
| SCHEMBL7984765 | 0.86 | GRM2 (0.36) | KDM4EMEN1ALDH1A1KMT2ABUB1 | |
| SCHEMBL7987693 | 0.83 | TDP1 (0.34) | TP53KDM4EALDH1A1KMT2ABUB1 | |
| SCHEMBL7991771 | 0.83 | KMT2A (0.39) | AURKARPS6KB1KDM4EALDH1A1KMT2A | |
| SCHEMBL7988995 | 0.83 | NR1H4 (0.38) | BUB1 | |
| SCHEMBL7974052 | 0.81 | KDM4E (0.42) | TP53KDM4EL3MBTL1RXFP1MAPT | |
| SCHEMBL7987938 | 0.81 | KDM4E (0.44) | TP53PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7992533 | 0.81 | GLS (0.38) | AURKARPS6KB1KDM4EALDH1A1KMT2A | |
| SCHEMBL7974433 | 0.81 | TP53 (0.40) | TP53AURKARPS6KB1MEN1KMT2A | |
| SCHEMBL7974264 | 0.79 | HTR2C (0.40) | AURKARPS6KB1BUB1GAAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |