SCHEMBL7984970

SCHEMBL7984970

COCOc1c(C)cc(-c2nc(=O)c3c(ncn3Cc3ccccc3)[nH]2)cc1C

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PARN O95453 1/20 0.43
CNOT7 Q9UIV1 1/20 0.43
P2RX7 Q99572 18/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7988685 0.88 PARN (0.41) PARNCNOT7P2RX7
SCHEMBL7984891 0.85 CNOT7 (0.50) PARNCNOT7P2RX7
SCHEMBL7984961 0.85 HPGD (0.48) PARNCNOT7P2RX7
SCHEMBL7985328 0.85 CNOT7 (0.51) PARNCNOT7P2RX7
SCHEMBL7985350 0.83 GAA (0.48) PARNCNOT7P2RX7
SCHEMBL7984414 0.82 KMT2A (0.44) PARNCNOT7P2RX7
SCHEMBL7975271 0.81 CNOT7 (0.56) PARNCNOT7
SCHEMBL7988597 0.80 PARN (0.48) PARNCNOT7P2RX7
SCHEMBL7985228 0.80 CXCR2 (0.50) PARNCNOT7P2RX7
SCHEMBL7988790 0.79 CNOT7 (0.53) PARNCNOT7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310070-B1 FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS JAPAN ENERGY CORPORATION (JP) 2001-10-30 US disclosed
EP-0999211-A1 NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF JAPAN ENERGY CORPORATION (JP) 2000-05-10 EP disclosed