Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744024 | 0.84 | HTT (0.47) | HTTPIM1ALDH1A1MEN1KMT2A | |
| SCHEMBL7132908 | 0.79 | GPR139 (0.42) | — | |
| SCHEMBL7074298 | 0.79 | RAB9A (0.44) | HTTALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7743927 | 0.71 | MEN1 (0.42) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL7737888 | 0.70 | GRM4 (0.44) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL26627416 | 0.70 | L3MBTL1 (0.56) | HTTALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27959536 | 0.69 | PIM1 (0.56) | HTTPIM1ALDH1A1MAPTNPC1 | |
| SCHEMBL7743468 | 0.69 | GRM4 (0.41) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL7743962 | 0.68 | F7 (0.46) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL7743905 | 0.67 | KMT2A (0.42) | HTTALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271236-B1 | PHENYL UREAS/THIOUREAS AS INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE ENZYME, USEFUL IN TREATING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, AND VARICELLA-ZOSTER VIRUS | WYETH | 2001-08-07 | — | — | US | disclosed |