Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372910 | 0.89 | LMNA (0.56) | LMNANPSR1TSHRALDH1A1PTPN1 | |
| SCHEMBL7978811 | 0.88 | PTPN1 (0.46) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL5590843 | 0.87 | NPSR1 (0.47) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL31518126 | 0.86 | AKR1B1 (0.47) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL7980326 | 0.85 | PTPN1 (0.44) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL27463138 | 0.85 | PTPN1 (0.59) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL9231424 | 0.81 | ALDH1A1 (0.43) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL12501297 | 0.81 | LMNA (0.46) | LMNANPSR1TSHRALDH1A1GLA | |
| SCHEMBL9931971 | 0.81 | LMNA (0.50) | LMNANPSR1TSHRKMT2AMEN1 | |
| SCHEMBL11225167 | 0.79 | MEN1 (0.56) | TSHRKMT2AMEN1POLBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |