Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985675 | 1.00 | SIGMAR1 (0.58) | SIGMAR1TDP1L3MBTL1CASP3ALDH1A1 | |
| SCHEMBL7986503 | 0.81 | KDM4E (0.56) | TDP1ALDH1A1KDM4E | |
| SCHEMBL7986506 | 0.81 | KDM4E (0.56) | TDP1ALDH1A1KDM4E | |
| SCHEMBL7983055 | 0.79 | SIGMAR1 (0.66) | SIGMAR1OPRM1 | |
| SCHEMBL30371663 | 0.78 | TDP1 (0.86) | TDP1L3MBTL1CASP3ALDH1A1KDM4E | |
| SCHEMBL45050 | 0.78 | TDP1 (0.86) | TDP1L3MBTL1CASP3ALDH1A1KDM4E | |
| SCHEMBL13442856 | 0.75 | CASP3 (0.81) | TDP1L3MBTL1CASP3ALDH1A1ALDH2 | |
| SCHEMBL3962101 | 0.74 | KDM4E (0.60) | SIGMAR1TDP1ALDH1A1KDM4E | |
| SCHEMBL6733250 | 0.74 | TP53 (0.52) | TDP1ALDH1A1KDM4ETSHRMAPK1 | |
| SCHEMBL3231915 | 0.73 | SIGMAR1 (1.00) | SIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |