Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996881 | 0.85 | LTA4H (0.65) | LTA4HHRH3KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10869155 | 0.82 | HRH3 (0.57) | LTA4HHRH3GRIN2DGRIN3BADRA1D | |
| Hydrochloric Acid SCHEMBL10869348 | 0.81 | HRH3 (0.56) | LTA4HHRH3ALDH1A1GRIN2DGRIN3B | |
| SCHEMBL6980055 | 0.81 | GRIN2D (0.56) | LTA4HHRH3GRIN2DGRIN3BADRA1D | |
| SCHEMBL28753859 | 0.80 | HTR1A (0.61) | — | |
| SCHEMBL7547846 | 0.80 | HTR1A (0.61) | — | |
| SCHEMBL8113980 | 0.79 | HTR1A (0.61) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL2476820 | 0.79 | LTA4H (1.00) | LTA4HHRH3HTTRAB9ANPC1 | |
| SCHEMBL7984081 | 0.79 | HTR1A (0.61) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL1508512 | 0.79 | LMNA (0.56) | LTA4HHTTRAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |