Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.40 |
| ▸ | APP | P05067 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22670400 | 0.72 | KMT2A (0.60) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7985908 | 0.69 | MAPT (0.35) | POLBMAPTKDM4EGAAAPP | |
| SCHEMBL7974687 | 0.68 | ROCK2 (0.47) | POLBCYP3A4 | |
| SCHEMBL12892198 | 0.67 | SMN1; SMN2 (0.56) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL2028396 | 0.66 | ADH5 (0.32) | — | |
| SCHEMBL9812745 | 0.66 | POLB (0.43) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL12384188 | 0.66 | POLB (0.76) | POLBMAPTKDM4ENPC1RAB9A | |
| SCHEMBL6074332 | 0.65 | ACHE (0.33) | POLBMAPT | |
| SCHEMBL184092 | 0.65 | DCUN1D1 (0.44) | POLBMAPTNPC1RAB9AGAA | |
| SCHEMBL7976721 | 0.65 | POLB (0.46) | POLBMAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |