Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.69 |
| ▸ | FLT1 | P17948 | 3/20 | 0.69 |
| ▸ | FLT4 | P35916 | 3/20 | 0.69 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976802 | 0.92 | KDR (0.59) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7976928 | 0.92 | KDR (0.59) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7553508 | 0.91 | KDR (0.69) | KDRFLT1FLT4CNR1CNR2 | |
| SCHEMBL7548749 | 0.90 | KDR (0.72) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7502516 | 0.90 | KDR (0.77) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7986598 | 0.87 | KDR (0.53) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7991008 | 0.87 | KDR (0.62) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7986691 | 0.87 | KDR (0.62) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7987902 | 0.86 | KDR (0.53) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7991259 | 0.86 | KDR (0.53) | KDRFLT1FLT4GSK3BNFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |