Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | FLT4 | P35916 | 4/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548212 | 0.88 | KDR (0.39) | KDRFLT1FLT4CYP2A6CHEK1 | |
| SCHEMBL7505916 | 0.88 | CCNT1 (0.38) | KDM1ACDK2PRKCZ | |
| SCHEMBL7510914 | 0.87 | KDR (0.51) | KDRFLT1FLT4CYP2A6CHEK1 | |
| SCHEMBL7976003 | 0.87 | PRKCZ (0.40) | KDRFLT1FLT4CYP2A6CHEK1 | |
| SCHEMBL7994416 | 0.87 | CCNT1 (0.37) | KDM1ACDK2 | |
| SCHEMBL7990500 | 0.85 | KDM1A (0.41) | KDM1ACHEK1 | |
| SCHEMBL7975983 | 0.85 | CCNT1 (0.36) | KDM1ACDK2 | |
| SCHEMBL7986901 | 0.83 | KDR (0.41) | KDRFLT1FLT4CYP2A6CHEK1 | |
| SCHEMBL7990463 | 0.83 | CHEK1 (0.39) | KDM1ACHEK1 | |
| SCHEMBL7994041 | 0.80 | KDR (0.41) | KDRFLT1FLT4CYP2A6CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |