Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | FLT4 | P35916 | 4/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987194 | 0.90 | HTR6 (0.37) | HTR6CHEK1CDK2PDE4BPDE4D | |
| SCHEMBL7548212 | 0.88 | KDR (0.39) | PRKCZKDRFLT1FLT4HTR6 | |
| SCHEMBL7990448 | 0.88 | CYP11B1 (0.40) | PRKCZHTR6CDK2PDE4BPDE4D | |
| SCHEMBL7975970 | 0.87 | HTR6 (0.39) | HTR6CHEK1PDE4BPDE4D | |
| SCHEMBL7510914 | 0.87 | KDR (0.51) | PRKCZKDRFLT1FLT4CYP2A6 | |
| SCHEMBL7993904 | 0.87 | KDR (0.38) | PRKCZKDRFLT1FLT4CYP2A6 | |
| SCHEMBL7990169 | 0.87 | PDE4B (0.37) | HTR6CDK2PDE4BPDE4D | |
| SCHEMBL7994041 | 0.85 | KDR (0.41) | PRKCZKDRFLT1FLT4PDGFRB | |
| SCHEMBL7993914 | 0.85 | HTR6 (0.38) | HTR6CDK2PDE4BPDE4D | |
| SCHEMBL7976151 | 0.83 | CCNT1 (0.37) | ALPLHTR6CHEK1CDK2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |