SCHEMBL7986906

SCHEMBL7986906

CCOc1cccc(Nc2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.54
KMT2A Q03164 4/20 0.54
MEN1 O00255 2/20 0.54
ALDH1A1 P00352 2/20 0.54
AR P10275 1/20 0.54
SYK P43405 1/20 0.54
PTK6 Q13882 1/20 0.52
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
HSD17B10 Q99714 2/20 0.51
LMNA P02545 1/20 0.51
MAPK1 P28482 1/20 0.51
HTT P42858 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
LTA4H P09960 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
ALOX12 P18054 1/20 0.49
RAB9A P51151 1/20 0.49
MTNR1B P49286 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11518974 0.94 SYK (0.57) MAPTKMT2AMEN1ALDH1A1SYK
SCHEMBL11191264 0.88 MTNR1B (0.52) MAPTKMT2AMEN1SYKPTK6
SCHEMBL11667711 0.87 KMT2A (0.47) MAPTKMT2AMEN1ALDH1A1AR
SCHEMBL27587753 0.86 CYP3A4 (0.59) MAPTKMT2AMEN1ALDH1A1SYK
SCHEMBL9502179 0.84 SYK (0.47) KMT2AMEN1SYKPTK6TP53
SCHEMBL3440767 0.82 MAPT (0.63) MAPTKMT2AMEN1ALDH1A1HSD17B10
SCHEMBL9479637 0.82 MAPT (0.63) MAPTKMT2AMEN1ALDH1A1HSD17B10
SCHEMBL8962118 0.82 TSHR (0.58) LTA4HNR1H4TSHR
SCHEMBL2089601 0.81 MAPT (0.54) MAPTKMT2AMEN1ALDH1A1AR
SCHEMBL27339343 0.81 KMT2A (0.61) MAPTKMT2AMEN1ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117089943-A Single-walled carbon nanotube reinforced heterocyclic aramid fiber and preparation method thereof 北京石墨烯研究院 2023-11-21 CN claimed
CN-117089943-A Single-walled carbon nanotube reinforced heterocyclic aramid fiber and preparation method thereof 北京石墨烯研究院 2023-11-21 CN disclosed
US-20200407658-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2020-12-31 US disclosed
US-10808197-B2 Alkylated alkoxydiarylamine antioxidants LANXESS SOLUTIONS US INC. (US) 2020-10-20 US disclosed
WO-2018057365-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS SOLUTIONS US INC. (US) 2018-03-29 WO disclosed
US-20180079984-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS LANXESS CORPORATION 2018-03-22 US disclosed
EP-2585216-A1 COMPLEXES Johnson Matthey PLC (GB) 2013-05-01 EP disclosed
US-8293715-B2 10a-Azalide compound crosslinked at 10a- and 12-positions TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-10-23 US disclosed
US-8293715-B2 10a-Azalide compound crosslinked at 10a- and 12-positions TAISHO PHARMACEUTICAL CO., LTD. (JP) 2012-10-23 US disclosed
WO-2011161451-A1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2011-12-29 WO disclosed
US-20110237784-A1 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-29 US disclosed
US-20110237784-A1 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-29 US disclosed
US-6218388-B1 THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE WARNER-LAMBERT COMPANY 2001-04-17 US disclosed
US-5990146-A TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS WARNER-LAMBERT COMPANY (US) 1999-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237784-A1 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS DCLRE1A, AZI2, CHD9 MAPT 4511/4885KMT2A 568/4885MEN1 3118/4885
US-10808197-B2 Alkylated alkoxydiarylamine antioxidants GPX4, CAT, SOD1 MAPT 2803/4885KMT2A 1818/4885MEN1 4755/4885
US-20200407658-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS GPX4, CAT, SOD1 MAPT 2803/4885KMT2A 1818/4885MEN1 4755/4885
US-20180079984-A1 ALKYLATED ALKOXYDIARYLAMINE ANTIOXIDANTS GPX4, CAT, SOD1 MAPT 2803/4885KMT2A 1818/4885MEN1 4755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.