Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239905 | 0.85 | KMT2A (0.52) | LTB4RLTB4R2ALDH1A1GAAMEN1 | |
| SCHEMBL7976117 | 0.82 | LTB4R (0.69) | LTB4RLTB4R2MAOBMRGPRX4MEN1 | |
| SCHEMBL7990262 | 0.78 | ALKBH1 (0.40) | LTB4RLTB4R2PDE4DMAOBGAA | |
| SCHEMBL29803481 | 0.78 | EGFR (0.64) | MAOBMRGPRX4ALDH1A1SYKEGFR | |
| SCHEMBL2088184 | 0.78 | MAOB (0.68) | MAOBMEN1KMT2A | |
| SCHEMBL1545310 | 0.78 | EGFR (0.64) | MAOBMRGPRX4ALDH1A1SYKEGFR | |
| SCHEMBL2087289 | 0.78 | MAOB (0.70) | MAOBALDH1A1GAA | |
| SCHEMBL8827253 | 0.75 | MAOB (0.48) | MAOBMRGPRX4ALDH1A1GAASYK | |
| SCHEMBL14611120 | 0.74 | TSHR (0.61) | LTB4RLTB4R2MRGPRX4PTGER1MEN1 | |
| SCHEMBL2089466 | 0.74 | KMT2A (0.57) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |