Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990641 | 0.83 | SGMS2 (0.52) | ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7987708 | 0.83 | SGMS2 (0.52) | ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7975824 | 0.83 | SGMS2 (0.52) | ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14862759 | 0.80 | KMT2A (0.45) | ALDH1A1HPGDSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL7975883 | 0.76 | POLB (0.47) | ALDH1A1HPGDSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL10897470 | 0.74 | TACR1 (0.41) | ALDH1A1HPGDSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL5511656 | 0.74 | KMT2A (0.56) | ALDH1A1HPGDSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL28104557 | 0.71 | LMNA (0.42) | ALDH1A1HPGDSMN1; SMN2LMNANPSR1 | |
| SCHEMBL11310166 | 0.71 | LMNA (0.42) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10709995 | 0.71 | SMN1; SMN2 (0.44) | ALDH1A1HPGDSMN1; SMN2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |