Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989643 | 0.84 | SGMS2 (0.50) | GAAALDH1A1MEN1KMT2A | |
| SCHEMBL7990565 | 0.84 | SGMS2 (0.50) | GAAALDH1A1MEN1KMT2A | |
| SCHEMBL7987324 | 0.76 | ALDH1A1 (0.47) | POLBSMN1; SMN2HPGDALDH1A1MEN1 | |
| SCHEMBL7990821 | 0.75 | TDP1 (0.47) | POLBALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL14874433 | 0.75 | POLB (0.47) | POLBSMN1; SMN2HPGDGAAALDH1A1 | |
| SCHEMBL8655892 | 0.74 | LMNA (0.48) | POLBSMN1; SMN2HPGDGAAALDH1A1 | |
| SCHEMBL8953561 | 0.73 | KMT2A (0.50) | POLBSMN1; SMN2HPGDGAAALDH1A1 | |
| SCHEMBL16815732 | 0.73 | KMT2A (0.50) | POLBSMN1; SMN2HPGDGAAALDH1A1 | |
| SCHEMBL463315 | 0.73 | KMT2A (0.50) | POLBSMN1; SMN2HPGDGAAALDH1A1 | |
| SCHEMBL1419560 | 0.73 | KMT2A (0.53) | POLBHPGDGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |