Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.44 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985852 | 0.90 | TP53 (0.52) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7989314 | 0.90 | ROCK2 (0.55) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7974021 | 0.89 | TP53 (0.51) | ROCK2TP53RXFP1ROCK1CNOT7 | |
| SCHEMBL7988938 | 0.88 | CNOT7 (0.48) | ROCK2NPY5RCNOT7CYP1A2CYP3A4 | |
| SCHEMBL7985655 | 0.87 | TP53 (0.48) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7974316 | 0.86 | TP53 (0.48) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7974096 | 0.86 | TP53 (0.48) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7984697 | 0.86 | TP53 (0.48) | ROCK2TP53RXFP1ROCK1AURKA | |
| SCHEMBL7985337 | 0.86 | CNOT7 (0.48) | ROCK2ROCK1CNOT7 | |
| SCHEMBL7988666 | 0.86 | CNOT7 (0.48) | ROCK2NPY5RCNOT7CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |