Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587107 | 0.71 | PDE4D (0.71) | PDE4APDE4BPDE4CPDE4DGRM5 | |
| SCHEMBL6586660 | 0.69 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586028 | 0.64 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DGRM5 | |
| SCHEMBL8330962 | 0.63 | GRM5 (0.47) | PDE4APDE4BPDE4CPDE4DGRM5 | |
| SCHEMBL29187194 | 0.61 | GRM5 (0.54) | GRM5 | |
| SCHEMBL432616 | 0.60 | SIGMAR1 (0.54) | IDO1 | |
| SCHEMBL28175144 | 0.60 | GRM5 (0.51) | GRM5IDO1 | |
| SCHEMBL5966248 | 0.59 | GRM5 (0.50) | GRM5IDO1 | |
| SCHEMBL27923940 | 0.59 | SIGMAR1 (0.52) | IDO1 | |
| SCHEMBL3058265 | 0.59 | CHRNB2 (0.59) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |