Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974490 | 0.89 | NR1H4 (0.47) | ADORA3ABCG2ADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7984973 | 0.88 | CXCR2 (0.44) | ADORA3ABCG2ADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7974072 | 0.88 | ADORA3 (0.43) | ADORA3ABCG2MMP13CXCR2POLB | |
| SCHEMBL7975267 | 0.88 | SMN1; SMN2 (0.46) | ADORA3ADORA2AALDH1A1SMN1; SMN2ADORA1 | |
| SCHEMBL7986521 | 0.87 | CYP11B1 (0.47) | ADORA3METADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7991405 | 0.86 | CYP11B1 (0.45) | ADORA3MDM2ADORA2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7984717 | 0.85 | SMN1; SMN2 (0.46) | ADORA3ADORA2AALDH1A1SMN1; SMN2ADORA1 | |
| SCHEMBL7988016 | 0.84 | HDAC1 (0.44) | ADORA3METMDM2 | |
| SCHEMBL7974441 | 0.83 | GRK2 (0.43) | ADORA3ADORA2AALDH1A1SMN1; SMN2CYP11B1 | |
| SCHEMBL7974507 | 0.82 | MET (0.46) | ADORA3METADORA2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |