Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974072 | 0.94 | ADORA3 (0.43) | CXCR2ADORA3GRIN2BGRIN1ABCG2 | |
| SCHEMBL7988016 | 0.90 | HDAC1 (0.44) | ADORA3HDAC1HDAC6CTSSCTSK | |
| SCHEMBL7987950 | 0.88 | ADORA3 (0.49) | CXCR2ADORA3ADORA2AABCG2ALDH1A1 | |
| SCHEMBL7987253 | 0.86 | HPGDS (0.40) | ADORA3HDAC1HDAC6ADORA2AABCG2 | |
| SCHEMBL7985336 | 0.85 | PIK3CA (0.42) | CXCR2ADORA3HDAC1HDAC6ADORA2A | |
| SCHEMBL7975267 | 0.85 | SMN1; SMN2 (0.46) | ADORA3ADORA2AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7974012 | 0.84 | ALDH1A1 (0.41) | CXCR2ADORA3HDAC1HDAC6ADORA2A | |
| SCHEMBL7984659 | 0.84 | ALDH1A1 (0.44) | ADORA3ADORA2AALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7987662 | 0.84 | ALDH1A1 (0.43) | ADORA3ADORA2AALDH1A1KDM4EMEN1 | |
| SCHEMBL7988594 | 0.84 | TP53 (0.44) | HDAC1HDAC6ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |