Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988522 | 0.90 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11ALDH1A1ADORA2A | |
| SCHEMBL7984932 | 0.90 | ABCC8 (0.43) | NR1H4ABCC8KCNJ11ADORA3CYP19A1 | |
| SCHEMBL7974277 | 0.89 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11ADORA3 | |
| SCHEMBL7987361 | 0.89 | MET (0.45) | NR1H4ABCC8KCNJ11 | |
| SCHEMBL7987950 | 0.89 | ADORA3 (0.49) | ADORA3ABCG2SMN1; SMN2ALDH1A1ADORA2A | |
| SCHEMBL7991400 | 0.88 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11HPGDALDH1A1 | |
| SCHEMBL7985010 | 0.88 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11SMN1; SMN2 | |
| SCHEMBL7974237 | 0.88 | KIF11 (0.42) | NR1H4ABCC8KCNJ11CYP19A1ABCG2 | |
| SCHEMBL7975267 | 0.88 | SMN1; SMN2 (0.46) | ADORA3HPGDSMN1; SMN2ALDH1A1ADORA2A | |
| SCHEMBL8056959 | 0.88 | NR1H4 (0.39) | NR1H4ABCC8KCNJ11ADORA3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |