SCHEMBL7987983

SCHEMBL7987983

CC(=O)Oc1ccc(CCOc2ccc(C=O)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.55
MAPT P10636 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
ALDH1A1 P00352 2/20 0.55
HPGD P15428 1/20 0.55
KMT2A Q03164 3/20 0.50
PPARG P37231 3/20 0.48
PPARA Q07869 1/20 0.48
FFAR1 O14842 1/20 0.47
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
TTR P02766 1/20 0.45
TP53 P04637 1/20 0.45
CYP3A4 P08684 1/20 0.45
S1PR1 P21453 2/20 0.44
S1PR3 Q99500 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA4 P22748 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL203500 0.82 KMT2A (0.61) LMNAMAPTSMN1; SMN2ALDH1A1KMT2A
SCHEMBL7996783 0.81 MAPT (0.57) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL3961218 0.81 FFAR1 (0.64) MAPTSMN1; SMN2ALDH1A1KMT2APPARG
SCHEMBL2231854 0.81 ALDH1A1 (0.61) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL2232493 0.81 ALDH1A1 (0.63) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL2231514 0.81 ALDH1A1 (0.63) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL2232274 0.81 ALDH1A1 (0.61) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL2231178 0.81 ALDH1A1 (0.66) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL7987753 0.81 PPARA (0.48) LMNAMAPTSMN1; SMN2ALDH1A1HPGD
SCHEMBL2992777 0.81 ALDH1A1 (0.58) LMNAMAPTSMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288096-B1 ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS ASTRAZENECA AB (SE) 2001-09-11 US disclosed
EP-0991632-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES Astra Aktiebolag (SE) 2000-04-12 EP disclosed
WO-1998057941-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES ASTRA AKTIEBOLAG (SE) 1998-12-23 WO disclosed