SCHEMBL7988196

SCHEMBL7988196

Cc1cc(-c2c(C)c(C(=O)O)cc(Cl)c2Cl)on1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.50
USP2 O75604 1/20 0.50
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
HCAR2 Q8TDS4 1/20 0.42
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
MAPK1 P28482 1/20 0.36
CSF1R P07333 7/20 0.36
FTO Q9C0B1 3/20 0.34
SORT1 Q99523 2/20 0.34
PRKAG1 P54619 1/20 0.34
PRKAA1 Q13131 1/20 0.34
PRKAB1 Q9Y478 1/20 0.34
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5704595 0.85 NOTUM (0.41) KDM4EUSP2ALDH1A1TSHRKMT2A
SCHEMBL5704541 0.83 LMNA (0.48) KDM4EUSP2ALDH1A1TSHRMAPK1
SCHEMBL5704593 0.82 CYP2C9 (0.37) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL5209607 0.80 ALDH1A1 (0.54) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL8138255 0.76 ALDH1A1 (0.49) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL7971081 0.74 ALDH1A1 (0.47) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL8135897 0.72 ALDH1A1 (0.48) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL5704507 0.72 ALDH1A1 (0.36) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL5204512 0.71 KDM4E (0.43) KDM4EUSP2ALDH1A1TSHRHCAR2
SCHEMBL27513006 0.71 ALDH1A1 (0.74) KDM4EUSP2ALDH1A1TSHRHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6245716-B1 LOW DOSAGE; NONPHYTOTOXIC NIPPON SODA CO., LTD. (JP) 2001-06-12 US disclosed