Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARN | O95453 | 1/20 | 0.40 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984210 | 0.91 | GRIN1 (0.43) | PDE1APDE1BPDE1CGRIN1GRIN2B | |
| SCHEMBL7988534 | 0.89 | TAAR1 (0.41) | PDE1APDE1BPDE1CGRIN1GRIN2B | |
| SCHEMBL7988665 | 0.88 | ALDH1A1 (0.44) | ALDH1A1TSHRPARNCNOT7HPGD | |
| SCHEMBL7991727 | 0.87 | SMN1; SMN2 (0.49) | MAPK1PARNCNOT7P2RX7 | |
| SCHEMBL7989504 | 0.87 | GRIN1 (0.41) | PDE1APDE1BPDE1CGRIN1GRIN2B | |
| SCHEMBL7988961 | 0.87 | KDM4E (0.42) | ALDH1A1TSHRMAPK1PARNCNOT7 | |
| SCHEMBL7989411 | 0.87 | CNOT7 (0.53) | ALDH1A1PARNCNOT7HPGDADORA2B | |
| SCHEMBL7984139 | 0.85 | TP53 (0.51) | ALDH1A1TSHRMAPK1HPGDROCK2 | |
| SCHEMBL7988482 | 0.83 | PDE1A (0.46) | PDE1APDE1BPDE1CGRIN1GRIN2B | |
| SCHEMBL7985863 | 0.82 | CNOT7 (0.57) | ALDH1A1PKMPARNCNOT7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |