Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984506 | 0.90 | EHMT2 (0.43) | NPC1SMN1; SMN2RAB9ASIRT2SIRT1 | |
| SCHEMBL7973823 | 0.89 | NPC1 (0.48) | NPC1RAB9ASIRT2SIRT1SIRT3 | |
| SCHEMBL7984200 | 0.88 | SMN1; SMN2 (0.53) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL7991860 | 0.84 | ADORA2A (0.46) | NPC1SMN1; SMN2RAB9ASIRT2SIRT1 | |
| SCHEMBL7988506 | 0.84 | NTRK1 (0.48) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL7985108 | 0.83 | EPHX2 (0.52) | NPC1SMN1; SMN2RAB9ASIRT2SIRT1 | |
| SCHEMBL7987763 | 0.83 | RAB9A (0.44) | NPC1SMN1; SMN2RAB9ASIRT2SIRT1 | |
| SCHEMBL7991586 | 0.79 | SMN1; SMN2 (0.49) | NPC1SMN1; SMN2RAB9ANFKB1NFKB2 | |
| SCHEMBL7974138 | 0.78 | KMT2A (0.52) | NPC1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL7988677 | 0.78 | SMN1; SMN2 (0.51) | NPC1SMN1; SMN2RAB9ASIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |