Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988677 | 0.95 | SMN1; SMN2 (0.51) | EPHX2KMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL7984506 | 0.91 | EHMT2 (0.43) | SMN1; SMN2RAB9ANPC1SIRT2SIRT1 | |
| SCHEMBL7991860 | 0.85 | ADORA2A (0.46) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL7973823 | 0.84 | NPC1 (0.48) | KMT2AMEN1RAB9ANPC1KDM4E | |
| SCHEMBL7988686 | 0.83 | NPC1 (0.47) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL7987763 | 0.80 | RAB9A (0.44) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL7974138 | 0.79 | KMT2A (0.52) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL7984889 | 0.79 | NPC1 (0.46) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 | |
| SCHEMBL7974555 | 0.79 | HDAC1 (0.45) | EPHX2KMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL7992620 | 0.78 | NPC1 (0.53) | KMT2ASMN1; SMN2MEN1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |