Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988506 | 0.94 | NTRK1 (0.48) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7991586 | 0.91 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7975241 | 0.89 | GAA (0.50) | SMN1; SMN2NPC1RAB9AADORA3FLT3 | |
| SCHEMBL7984492 | 0.88 | ADORA2A (0.53) | ADORA3KCNK3CDC7AURKADAPK3 | |
| SCHEMBL7986770 | 0.88 | NR1H4 (0.48) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7973841 | 0.88 | RAB9A (0.47) | NPC1RAB9AMEN1KMT2AHSD17B13 | |
| SCHEMBL7985255 | 0.88 | ALDH1A1 (0.51) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7988686 | 0.88 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL7985033 | 0.87 | NLRP3 (0.46) | SMN1; SMN2NPC1RAB9AADORA3MEN1 | |
| SCHEMBL7985560 | 0.87 | ADORA3 (0.52) | ADORA3KCNK3AURKARPS6KB1KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |