Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 9/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MTR | Q99707 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656701 | 0.81 | MGLL (0.35) | MGLLMTR | |
| SCHEMBL798970 | 0.79 | DHFR (0.42) | DHFRHSD11B1MEN1KMT2AKDM2B | |
| SCHEMBL798809 | 0.78 | GAA (0.39) | DHFRMEN1KMT2AKDM2B | |
| SCHEMBL655196 | 0.62 | PI4KB (0.68) | MEN1KMT2A | |
| SCHEMBL656130 | 0.61 | FPR2 (0.39) | MGLL | |
| SCHEMBL6704755 | 0.59 | DHFR (0.74) | DHFR | |
| SCHEMBL13574242 | 0.58 | MGLL (0.48) | MGLLMEN1KMT2AKDM2B | |
| SCHEMBL18577083 | 0.58 | MGLL (0.48) | MGLLMEN1KMT2AKDM2B | |
| SCHEMBL18577081 | 0.58 | MGLL (0.48) | MGLLMEN1KMT2AKDM2B | |
| SCHEMBL6701535 | 0.56 | DHFR (0.68) | DHFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |