Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655783 | 0.84 | DHFR (0.38) | DHFRKDM2BKMT2AMEN1NPSR1 | |
| SCHEMBL798809 | 0.76 | GAA (0.39) | DHFRKDM2BKMT2AMEN1ALDH1A1 | |
| SCHEMBL656125 | 0.67 | FPR2 (0.40) | KDM2BKMT2AMEN1NPSR1L3MBTL1 | |
| SCHEMBL3188892 | 0.65 | UBE2M (0.51) | L3MBTL1ALDH1A1HSD11B1HPGDKDM4E | |
| SCHEMBL26698259 | 0.64 | KDM2B (0.57) | KDM2BKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL4776118 | 0.64 | KDM2B (0.51) | KDM2BKMT2AMEN1ALDH1A1HSD11B1 | |
| SCHEMBL7309424 | 0.63 | CES2 (0.65) | KDM2BKMT2AMEN1HSD11B1SMN1; SMN2 | |
| SCHEMBL31636008 | 0.63 | CES2 (0.65) | KDM2BKMT2AMEN1HSD11B1SMN1; SMN2 | |
| SCHEMBL5210032 | 0.62 | MGLL (0.62) | KDM2BKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL30771226 | 0.62 | MGLL (0.62) | KDM2BKMT2AMEN1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |