Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989597 | 0.91 | SIRT2 (0.53) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL7991728 | 0.82 | SIRT2 (0.53) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL7988569 | 0.82 | ALOX5 (0.48) | SIRT2SIRT1SIRT3TP53TARBP2 | |
| SCHEMBL7995187 | 0.81 | AR (0.53) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL7989599 | 0.81 | SIRT2 (0.52) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL7989451 | 0.81 | ALOX5 (0.58) | TP53GCGRALOX5GABRA2GABRB2 | |
| SCHEMBL7989950 | 0.81 | MAPK13 (0.51) | MDM2TARBP2ALOX5MAPTSMN1; SMN2 | |
| SCHEMBL7990062 | 0.80 | SIRT2 (0.53) | SIRT2SIRT1SIRT3TP53TARBP2 | |
| SCHEMBL7991839 | 0.80 | SIRT2 (0.50) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL7989526 | 0.80 | SIRT2 (0.50) | SIRT2SIRT1SIRT3TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |