Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 4/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4142895 | 0.81 | KDM4E (0.42) | ALDH1A1 | |
| SCHEMBL3244780 | 0.80 | CTSV (0.44) | ALDH1A1 | |
| SCHEMBL928608 | 0.80 | ALDH1A1 (0.47) | SLC6A4HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL6470274 | 0.78 | CHRNB2 (0.41) | HTR2AALDH1A1 | |
| SCHEMBL16432092 | 0.74 | TAAR1 (0.46) | SLC6A4HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL640081 | 0.73 | KIF11 (0.39) | ALDH1A1 | |
| SCHEMBL7404828 | 0.70 | HTR2A (0.36) | HTR2AHTR2CHTR2BHTR6MPO | |
| SCHEMBL3381548 | 0.70 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1 | |
| SCHEMBL4724357 | 0.70 | AHR (0.38) | SLC6A4HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL5327645 | 0.70 | ALDH1A1 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |