Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6195857 | 0.92 | TSHR (0.46) | GAATSHRBLMPKMMEN1 | |
| SCHEMBL6791270 | 0.88 | GAA (0.49) | GAATSHRBLMPKMMEN1 | |
| SCHEMBL6196412 | 0.87 | ADRA1A (0.42) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL6197708 | 0.83 | ADRA1A (0.38) | POLB | |
| SCHEMBL6199413 | 0.79 | PKM (0.52) | GAATSHRBLMPKMMEN1 | |
| SCHEMBL6198077 | 0.76 | PKM (0.45) | GAATSHRBLMPKMMEN1 | |
| SCHEMBL6643652 | 0.76 | FFAR2 (0.34) | ALDH1A1 | |
| SCHEMBL6196437 | 0.74 | POLB (0.35) | GAATSHRMEN1KMT2AKDM4E | |
| SCHEMBL6788796 | 0.73 | HTT (0.53) | GAATSHRBLMPKMMEN1 | |
| SCHEMBL6195197 | 0.73 | ALDH1A1 (0.39) | GAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228861-B1 | BENIGN PROSTATIC HYPERPLASIA; ANTICHOLESTEROL AGENTS; IMPOTENCY; INTRAOCULAR PRESSURE; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-05-08 | — | — | US | disclosed |
| EP-0866708-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0866708-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997017969-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |