Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582159 | 0.84 | HPGD (0.47) | ALDH1A1HPGDKDM4ERAB9ANPC1 | |
| SCHEMBL7296122 | 0.78 | DHPS (0.53) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL7585609 | 0.78 | EDNRB (0.51) | — | |
| SCHEMBL8398581 | 0.78 | NPBWR1 (0.35) | ALDH1A1HPGDKDM4ERAB9ANPC1 | |
| SCHEMBL7303236 | 0.78 | CLK4 (0.51) | ALDH1A1KDM4ERAB9ASMN1; SMN2MAPT | |
| SCHEMBL7580836 | 0.78 | EDNRA (0.44) | — | |
| SCHEMBL7298473 | 0.77 | DHPS (0.47) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7990139 | 0.76 | MAPT (0.58) | HPGDKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7589754 | 0.76 | EDNRA (0.47) | — | |
| SCHEMBL9423667 | 0.74 | NPC1 (0.52) | ALDH1A1HPGDKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768304-B1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | HOFFMANN LA ROCHE (CH) | 2002-05-22 | — | — | EP | disclosed |
| US-5856484-A | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0768304-A1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1997-04-16 | — | — | EP | disclosed |