Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.71 |
| ▸ | FLT1 | P17948 | 4/20 | 0.71 |
| ▸ | FLT4 | P35916 | 4/20 | 0.71 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990694 | 0.88 | KDR (0.56) | KDRFLT1FLT4CNR2 | |
| SCHEMBL7990501 | 0.87 | KDR (0.58) | KDRFLT1FLT4CYP2A6CNR2 | |
| SCHEMBL7545417 | 0.86 | KDR (0.52) | KDRFLT1FLT4CNR2ALPL | |
| SCHEMBL7547229 | 0.86 | KDR (0.51) | KDRFLT1FLT4CNR2PDGFRB | |
| SCHEMBL7504851 | 0.86 | KDR (0.51) | KDRFLT1FLT4CNR2ALPL | |
| SCHEMBL7546769 | 0.85 | KDR (0.51) | KDRFLT1FLT4CNR2ALPL | |
| SCHEMBL7990971 | 0.84 | KDR (0.70) | KDRFLT1FLT4CYP2A6CNR2 | |
| SCHEMBL7547755 | 0.83 | KDR (1.00) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7550053 | 0.81 | KDR (0.75) | KDRFLT1FLT4CYP2A6PDGFRB | |
| SCHEMBL7990673 | 0.78 | KDR (0.69) | KDRFLT1FLT4CYP2A6CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |