Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976294 | 0.89 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3MAPTSMN1; SMN2 | |
| SCHEMBL7986584 | 0.85 | EDNRA (0.40) | SLC6A2SLC6A4SLC6A3MAPTSMN1; SMN2 | |
| SCHEMBL7987577 | 0.76 | NPC1 (0.48) | MAPTSMN1; SMN2HPGDKDM4EHTT | |
| SCHEMBL7977103 | 0.75 | EDNRA (0.49) | MAPTSMN1; SMN2EDNRANPC1RAB9A | |
| SCHEMBL7975878 | 0.75 | TRPM8 (0.44) | MAPTSMN1; SMN2TRPM8HPGDEDNRA | |
| SCHEMBL7993896 | 0.73 | TRPM8 (0.43) | MAPTSMN1; SMN2TRPM8HPGDEDNRA | |
| SCHEMBL7975974 | 0.70 | MAPK9 (0.49) | SMN1; SMN2HPGDEDNRANPC1RAB9A | |
| SCHEMBL7976824 | 0.69 | HPGD (0.46) | MAPTSMN1; SMN2HPGDKDM4ELMNA | |
| SCHEMBL7993759 | 0.68 | MME (0.52) | HPGDKDM4EHTT | |
| SCHEMBL10653725 | 0.67 | TRPM8 (0.45) | TRPM8LMNANPC1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |