Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975878 | 0.90 | TRPM8 (0.44) | TRPM8EDNRAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7993894 | 0.76 | RXFP1 (0.42) | EDNRAKMT2AMEN1TSHRGAA | |
| SCHEMBL7987577 | 0.75 | NPC1 (0.48) | KMT2AMEN1TSHRALDH1A1MAPT | |
| SCHEMBL7990600 | 0.73 | SLC6A2 (0.43) | TRPM8EDNRAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7976294 | 0.72 | SLC6A2 (0.42) | TRPM8EDNRAKMT2AMEN1L3MBTL1 | |
| SCHEMBL7993759 | 0.71 | MME (0.52) | TSHRALDH1A1HPGDHTT | |
| SCHEMBL7986584 | 0.71 | EDNRA (0.40) | EDNRAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7975874 | 0.70 | RXFP1 (0.44) | TRPM8EDNRAKMT2AMEN1MAPT | |
| SCHEMBL7993650 | 0.70 | EDNRA (0.49) | EDNRATSHRALDH1A1MAPTHPGD | |
| SCHEMBL7976824 | 0.70 | HPGD (0.46) | KMT2AMEN1L3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |