Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380557 | 0.76 | XDH (0.85) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL7992963 | 0.74 | GSK3B (0.79) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL5390251 | 0.69 | GSK3B (0.59) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL10840696 | 0.69 | GSK3B (0.60) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL5375274 | 0.68 | XDH (0.55) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL7990975 | 0.68 | HSD17B10 (0.49) | CDC7ROCK2CLK4CYP3A4CYP2C9 | |
| SCHEMBL5383599 | 0.67 | ADORA2A (0.62) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL7978487 | 0.67 | GSK3B (0.48) | GSK3BCDC7ROCK2DBF4ROCK1 | |
| SCHEMBL7978376 | 0.65 | ROCK2 (0.41) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL7990740 | 0.65 | ROCK2 (0.40) | GSK3BCDC7ROCK2MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070727-A1 | 2-(ARYLALKYLAMINO)PYRIMIDONE DERIVATIVES AND 2-(HETEROARYLALKYLAMINO)PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | claimed |