Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | DMPK | Q09013 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996126 | 0.84 | GSK3B (0.63) | GSK3BXDH | |
| SCHEMBL7978702 | 0.80 | GSK3B (0.59) | GSK3BXDH | |
| SCHEMBL7992592 | 0.78 | GSK3B (0.56) | GSK3BXDH | |
| SCHEMBL7992743 | 0.76 | GSK3B (0.56) | GSK3BXDH | |
| SCHEMBL7992651 | 0.74 | LMNA (0.46) | GSK3BROCK2ROCK1 | |
| SCHEMBL5379886 | 0.72 | GSK3B (0.58) | GSK3BXDHROCK2ROCK1CDC42BPA | |
| SCHEMBL7978487 | 0.71 | GSK3B (0.48) | GSK3BROCK2ROCK1 | |
| SCHEMBL7993214 | 0.70 | GSK3B (0.48) | GSK3BXDHROCK2ROCK1 | |
| SCHEMBL5391514 | 0.70 | GSK3B (0.60) | GSK3BXDHROCK2ROCK1 | |
| SCHEMBL7990574 | 0.70 | LMNA (0.42) | GSK3BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070727-A1 | 2-(ARYLALKYLAMINO)PYRIMIDONE DERIVATIVES AND 2-(HETEROARYLALKYLAMINO)PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | claimed |
| WO-2001070727-A1 | 2-(ARYLALKYLAMINO)PYRIMIDONE DERIVATIVES AND 2-(HETEROARYLALKYLAMINO)PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | disclosed |