Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 9/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989179 | 0.87 | PDE4A (0.37) | MAPK8MAPK10PDE4AKCNH2SCN9A | |
| SCHEMBL7991272 | 0.82 | LMNA (0.50) | PDE4ASCN9ALMNA | |
| SCHEMBL7977060 | 0.82 | HSPB1 (0.48) | LMNA | |
| SCHEMBL7976870 | 0.80 | PDE4A (0.56) | PDE4AKCNH2 | |
| SCHEMBL7381889 | 0.78 | PDE4A (0.65) | PDE4AKCNH2 | |
| SCHEMBL7994597 | 0.77 | LMNA (0.43) | MAPK8MAPK10PDE4ALMNALIPE | |
| SCHEMBL7991148 | 0.74 | PDE4A (0.34) | MAPK8MAPK10PDE4ASCN9ASCN10A | |
| SCHEMBL5942690 | 0.73 | PDE4A (0.40) | PDE4AKCNH2 | |
| SCHEMBL7991436 | 0.70 | PDE4A (0.38) | PDE4AKCNH2 | |
| SCHEMBL7977065 | 0.70 | LMNA (0.51) | PDE4ASCN9ASCN10ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |