Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991282 | 0.87 | LMNA (0.54) | LMNALIPEPDE4APDE4BPDE4C | |
| SCHEMBL7994711 | 0.83 | RAB9A (0.49) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7989179 | 0.79 | PDE4A (0.37) | LMNALIPEPDE4AMAPK8MAPK10 | |
| SCHEMBL7991052 | 0.77 | MAPK8 (0.34) | LMNALIPEPDE4AMAPK8MAPK10 | |
| SCHEMBL18986986 | 0.75 | LMNA (0.56) | LMNALIPEVNN1NPC1RAB9A | |
| SCHEMBL5530111 | 0.75 | OPRM1 (0.56) | LMNALIPEMAPK8MAPK10SLC6A2 | |
| SCHEMBL7908376 | 0.74 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10392459 | 0.73 | LMNA (0.59) | LMNALIPE | |
| SCHEMBL9607063 | 0.72 | LMNA (0.53) | LMNALIPEVNN1HRH3 | |
| SCHEMBL7977065 | 0.72 | LMNA (0.51) | LMNAPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180650-B1 | ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTITUMOR AGENTS | MERCK FROSST CANADA & CO. (CA) | 2001-01-30 | — | — | US | disclosed |