Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.40 |
| ▸ | MMP13 | P45452 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 11/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991332 | 0.79 | MMP9 (0.49) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL8005756 | 0.78 | MMP2 (0.50) | MMP2MMP13MMP1TP53MMP9 | |
| SCHEMBL7998634 | 0.77 | MMP9 (0.46) | MMP2MMP13MMP1MMP9MMP14 | |
| SCHEMBL7365907 | 0.72 | MMP2 (0.48) | MMP2MMP13MMP1TP53MMP9 | |
| SCHEMBL7998631 | 0.69 | MMP2 (0.74) | MMP2MMP1MMP9 | |
| SCHEMBL8001932 | 0.67 | MMP2 (0.52) | MMP2MMP13MMP1TP53MMP9 | |
| SCHEMBL7593988 | 0.67 | MMP2 (0.44) | MMP2MMP13MMP1MMP9MMP14 | |
| SCHEMBL8005755 | 0.64 | MMP9 (0.59) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL16712121 | 0.64 | PPARG (0.41) | — | |
| SCHEMBL8000462 | 0.64 | MMP2 (0.52) | MMP2MMP13MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |