Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.48 |
| ▸ | MMP1 | P03956 | 9/20 | 0.48 |
| ▸ | MMP13 | P45452 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 10/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358588 | 0.88 | MMP13 (0.62) | MMP2MMP1MMP13MMP9 | |
| SCHEMBL8005756 | 0.83 | MMP2 (0.50) | MMP2MMP1MMP13TP53MMP9 | |
| SCHEMBL8001932 | 0.75 | MMP2 (0.52) | MMP2MMP1MMP13TP53MMP9 | |
| SCHEMBL7365905 | 0.75 | MMP9 (0.57) | MMP2MMP1MMP9 | |
| SCHEMBL8005755 | 0.72 | MMP9 (0.59) | MMP2MMP1MMP13MMP9MMP3 | |
| SCHEMBL7991334 | 0.72 | MMP2 (0.40) | MMP2MMP1MMP13TP53MMP9 | |
| SCHEMBL8000462 | 0.72 | MMP2 (0.52) | MMP2MMP1MMP13MMP9MMP14 | |
| SCHEMBL7539100 | 0.71 | MMP2 (0.50) | MMP2MMP1MMP13TP53MMP9 | |
| SCHEMBL7356347 | 0.70 | MMP9 (0.45) | MMP2MMP1MMP13TP53MMP9 | |
| SCHEMBL14572900 | 0.70 | MMP2 (0.55) | MMP2MMP1MMP13TP53MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | claimed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | claimed |
| US-6235786-B1 | RHEUMATIC DISORDERS; BONE DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-22 | — | — | US | disclosed |
| WO-2000044712-A1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 2000-08-03 | — | — | WO | disclosed |