Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 11/20 | 0.82 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.52 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.52 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 10/20 | 0.82 |
| ▸ | DRD3 | P35462 | 10/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7991707 | 1.00 | DRD2 (0.82) | DRD2DRD4DRD3KDM4ELMNA | |
| SCHEMBL7505101 | 0.91 | DRD2 (1.00) | DRD2DRD4DRD3KDM4EALDH1A1 | |
| Maleic Acid SCHEMBL7991244 | 0.88 | DRD2 (0.81) | DRD2DRD4DRD3KDM4ELMNA | |
| Fumaric Acid SCHEMBL7991247 | 0.88 | DRD2 (0.81) | DRD2DRD4DRD3KDM4ELMNA | |
| Maleic Acid SCHEMBL7988476 | 0.81 | DRD2 (0.81) | DRD2DRD4DRD3KDM4ELMNA | |
| Fumaric Acid SCHEMBL7988479 | 0.81 | DRD2 (0.81) | DRD2DRD4DRD3KDM4ELMNA | |
| SCHEMBL7504486 | 0.79 | DRD2 (1.00) | DRD2DRD4DRD3KDM4ELMNA | |
| Fumaric Acid SCHEMBL7977306 | 0.78 | KDM4E (0.53) | DRD2DRD4DRD3KDM4ELMNA | |
| SCHEMBL7503409 | 0.78 | DRD2 (1.00) | DRD2DRD4DRD3ALDH1A1HTR1A | |
| Hydrochloric Acid SCHEMBL7991758 | 0.77 | DRD2 (0.96) | DRD2DRD4DRD3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |