Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.51 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.47 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7991244 | 0.80 | DRD2 (0.81) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| Fumaric Acid SCHEMBL7991247 | 0.80 | DRD2 (0.81) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| Fumaric Acid SCHEMBL7991707 | 0.78 | DRD2 (0.82) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| Maleic Acid SCHEMBL7991705 | 0.78 | DRD2 (0.82) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| SCHEMBL1540163 | 0.77 | HTR2A (0.52) | KDM4ELMNAPOLBALDH1A1DRD2 | |
| SCHEMBL1111701 | 0.75 | TRPV1 (0.43) | KDM4ELMNAPOLBALDH1A1DRD2 | |
| SCHEMBL1540160 | 0.75 | HTR2A (0.52) | KDM4ELMNAPOLBALDH1A1DRD2 | |
| Fumaric Acid SCHEMBL7988479 | 0.74 | DRD2 (0.81) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| Maleic Acid SCHEMBL7988476 | 0.74 | DRD2 (0.81) | KDM4ELMNAPMP22ALDH1A1DRD2 | |
| SCHEMBL4249777 | 0.74 | KDM4E (0.59) | KDM4ELMNAPOLBALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | claimed |