Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.60 |
| ▸ | CES1 | P23141 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757531 | 0.87 | CES2 (0.65) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL6047416 | 0.82 | CES2 (0.79) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL10873516 | 0.81 | TSHR (0.56) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL6748632 | 0.77 | MAPT (0.53) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL6748634 | 0.77 | MAPT (0.53) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL167254 | 0.77 | CES2 (1.00) | CES2CES1TDP1ALDH1A1NPC1 | |
| SCHEMBL9300725 | 0.75 | TDP1 (0.57) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL21738822 | 0.75 | TDP1 (0.57) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL9043691 | 0.74 | MAPT (0.59) | CES2CES1TDP1ALDH1A1MAPT | |
| SCHEMBL8061017 | 0.73 | ALDH1A1 (0.56) | CES2CES1TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |