Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.79 |
| ▸ | HTR7 | P34969 | 5/20 | 0.69 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497271 | 0.92 | DRD4 (0.65) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL7991732 | 0.89 | DRD4 (1.00) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL12962319 | 0.84 | DRD4 (0.91) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL7506230 | 0.84 | DRD4 (0.56) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL15937972 | 0.82 | HTR7 (1.00) | DRD4HTR7DRD2DRD3MAPK1 | |
| Maleic Acid SCHEMBL7977396 | 0.81 | DRD4 (0.83) | DRD4HTR7DRD2DRD3HTR1A | |
| Fumaric Acid SCHEMBL7977401 | 0.81 | DRD4 (0.83) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL7507938 | 0.81 | SLC2A1 (0.58) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL15938266 | 0.81 | HTR7 (0.83) | DRD4HTR7DRD2DRD3MAPK1 | |
| SCHEMBL7499748 | 0.81 | SLC2A1 (0.57) | DRD4HTR7DRD2DRD3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |